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KMID : 0644120110240010027
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Journal of Oriental Gynecology
2011 Volume.24 No. 1 p.27 ~ p.41
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Effects of Ojeok-san on the Maturation of Follicles and NGF Expression in Rats with Estradiol Valerate-induced Polycystic Ovaries
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Kim Jong-Dae
Seo Il-Bock
Lee Dong-Nyung
Kim Hyung-Jun
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Abstract
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Objectives: This study was designed to investigate the effect of Ojeok-san(OJS) on the estradiol valerate(EV)-induced polycystic ovaries(PCO) in rats.
Methods: PCO was induced by single intramuscular injection with estradiol valerate(EV)(4mg) in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for sixty days. PCO control group (n=8) were injected with EV and orally administrated distilled water for sixty days. OJS treated group(n=8) were injected with EV and orally administrated OJS for sixty days. Then, we measured weights of body, ovaries, adrenal glands and uterus of rats. The histomorphometrical changes of ovaries were also evaluated. And we observed the NGF and CRF expression by immunohistochemistry.
Results: The results were as follows - The weights(mg) of ovaries in OJS treated group() were significantly increased(p < 0.05) compared with PCO control group(). - The numbers of mature follicles in OJS treated group() were significantly increased(p < 0.05) compared with PCO control group(). - The expressions of NGF-immunoreactive cells in the ovarian granulosa cells in OJS treated group were weaker than PCO control group.
Conclusion: From the these results, we concluded that Ojeok-san(OJS) has inhibitory effect on the development of EV-induced polycystic ovary. And it’s effect maybe related with decreased NGF activities in the ovary.
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KEYWORD
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Ojeok-san, Polycystic ovaries(PCO), Estradiol valerate(EV), Nerve growth factor(NGF), Ovarian histopathology
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